Coenzyme Q redox signalling and longevity

Mitochondria are the powerhouses of cell. They produce a significant amount energy we need to grow, survive and reproduce. The same system that generates in form ATP also produces Reactive Oxygen Species (ROS). Mitochondrial (mtROS) were considered for many years toxic by-products metabolism, responsible ageing degenerative diseases. Today, know mtROS essential redox messengers required determine cell fate maintain cellular homeostasis. Most produced by respiratory complex I (CI) III (CIII). How when CI CIII ROS is determined state Coenzyme Q (CoQ) pool proton motive force (pmf) generated during respiration. During ageing, there an accumulation defective mitochondria generate high levels mtROS. This causes oxidative stress disrupts signalling. Here, review how young old derived control physiological pathological processes. Finally, discuss why damaged amass as well methods preserve mitochondrial signalling with age.